Anti-Rat CD4 (Clone OX-38) - Purified <i>in vivo </i>PLATINUM™ Functional Grade - 100 mg

Depletion, ELISA, FA, FC, IP

2 - 8°C Wet Ice

CD4 is a 55 kD single-chain type I transmembrane glycoprotein with four domains and is amember of the Ig superfamily1, 2. CD4 functions primarily as a coreceptor for the MHC class IImolecule-peptide complex and initiates the early phase of T-cell activation via its associationwith the T-cell receptor complex and protein tyrosine kinase Lck3. In addition, CD4 Tlymphocytes are essential to the host response against infectious disease4 and CD4 T cellsmediate neuronal damage in infectious and immune-mediated diseases of the central nervoussystem5. In macrophages and natural killer cells, CD4 plays a role in differentiation/activation, cytokine expression and cell migration3. OX-38 was generated by immunizing mice with lymphocytes or thymocyte glycoproteins andsubsequently fusing mouse spleen cells with the P3-X63/Ag 8 cell line6. OX-38 is a depletingmonoclonal antibody used to study tolerance to allografts7, 8, 9, 10, 11, Pneumocystis-host interaction4, and alopecia12 in rat models.

≥ 5.0 mg/ml

CD4 is expressed on most thymocytes, a subset of T cells, and onmonocytes/macrophages.