Anti-Human DAD1 - 20 µg

Primary Monoclonal Antibodies>Apoptosis & Cell Biology

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Defender of cell death 1 (DAD1) was initially discovered in BHK21 cells as a negative regulator of programmed cell death1, a process important for normal organism development and tissue homeostasis.2 DAD1 was later shown to be a subunit of the mammalian oligosaccharyltransferase complex and is required for its function and structural integrity.3, 4 Mice lacking DAD1 express abnormal N-linked glycoproteins and undergo increased apoptotic-associated embryonic death.5, 6 Furthermore, overexpression of DAD1 mRNA is seen in some human hepatocellular carcinomas7, indicating it may also play a role in carcinogenesis. It should be noted that DAD1 is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

DAD1 Antibody, OST2, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1, Defender against cell death 1, Oligosaccharyl transferase subunit DAD1