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Anti-Mouse FOXP3 [MF-14] – Dylight® 550 - 50 µg

ArtNr LEIN-F409-50ug
Hersteller Leinco Technologies
Menge 50 ug
Quantity options 250 ug 50 ug
Kategorie
Typ Antibody Monoclonal
Applikationen WB, FC, IHC, IC
Clon MF-14
Specific against Mouse (Murine, Mus musculus)
Formula This DyLight® 550 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Versandbedingung Gekühlt
Lieferbar
Manufacturer - Category
Primary Monoclonal Antibodies>Apoptosis & Cell Biology|Monoclonal Antibodies|Primary Monoclonal Antibodies>Subcellular Organelles
Manufacturer - Targets
Foxp3
Shipping Temperature
Next Day 2 - 8°C
Storage Conditions
This DyLight® 550 conjugate is stable when stored at 2-8°C. Do not freeze.
Product Description
FOXP3 is a transcription factor1 required for development of CD4+CD25+ regulatory T cells (Treg) that does not affect CD4+CD25− T cell proliferation2. Treg cells expressing FOXP3 play a critical role in the maintenance of immune homeostasis and prevention of autoimmunity1. FOXP3 promotes the generation of Tregs, represses cytokine expression in primary CD4+ T cells, and suppresses the transcriptional activities of NFAT and NF-κB3. FOXP3 also inhibits basal activation of PKC-θ, IκB kinase β (IKKβ), and TNF-α stimulation of NF-κB. Depletion of FOXP3+CD4+ Treg cells and/or loss of function mutations of FOXP3 results in severe autoimmunity, allergy, immunopathology as well as cancer immunity1.FOXP3 is predominantly expressed in CD25+CD4+ Tregs in the thymus and periphery2, 4, and abundance increases upon in vitro activation of CD4+CD25+ Tregs2. Additionally, expression of FOXP3 in naïve T cells can convert these cells to a Treg phenotype4. FOXP3 is virtually undetectable in resting and activated CD4+CD25− T cells2. FOXP3 represents a more specific marker for CD4+ Tregs than e.g., CD25, CD45RB, CTLA-4, and GITR which do not discriminate between Tregs and activated, effector, or memory T cells4.
Manufacturer - Research Area
Cancer, Immuno-Oncology, Immunology, Oncology
Concentration
0.2 mg/ml
Formulation
This DyLight® 550 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Antigen Distribution
FOXP3 is a unique marker of CD4+CD25+ regulatory T cells, distinguishing them from activated CD4+CD25− T cells.
Protein
Foxp3
Keywords
Monoclonal Antibody, Foxp3, Forkhead box P3, Scurfin, Mouse FoxP3, Anti-Foxp3-PE

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50 ug
Lieferbar: In stock
lieferbar

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