Recombinant Mouse PD-L1 - 100 µg

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Murine Programmed Death-Ligand 1 (PD-L1) is a protein that is a part of the immune checkpointpathway which regulates the system used to balance the interaction between tumor cells and immunesurveillance1. Unlike PD-1, which is mainly found on T-cells and acts as a receptor, PD-L1 ispredominantly present on tumor cells and antigen-presenting cells. It serves as a mediator of immunetolerance by exploiting natural pathways that prevent autoimmunity. Tumors can evade the immunesystem and avoid detection by expressing PD-L1, inhibiting T-cell activation2. Inflammatory cytokines inthe tumor microenvironment further enhance this evasion strategy by increasing PD-L1 expression3.This highlights how tumors adapt and utilize the body's checkpoints for survival and growth. Thecomplex involvement of PD-L1 in both tolerance and cancer immunoevasion emphasizes its significanceas a target, for therapy. Blocking PD-L1 aims to dismantle the shield it provides to tumors allowing theimmune system to regain its ability to eliminate cells4.While mouse and human PD-L1 are similar in function, there are significant differences in how they areexpressed, regulated, and interact at a molecular level. These differences are crucial to accuratelytranslate research findings from mouse models to applications. They highlight the significance of usingmouse PD-L1 as a research tool to understand immune regulation mechanisms and develop targetedtherapies5. By understanding these species nuances we can better evaluate PD-L1 inhibitors leading toadvancements in immunotherapy, for cancer and autoimmune diseases.