Fumarate hydratase-IN-1

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mM*1mL (in DMSO)
ArtNr HY-100004-10mM
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
CAS No.
1644060-37-6
Purity
>98%
MW
4465381
Formula
C27H30N2O4
Solubility
10 mM in DMSO
Biological Description
Fumarate hydratase-IN-1, an enzyme of the TCA cycle. Inhibition of fumarate hydratase-IN-1 can contribute to tumorigenicity in some cells. The use of a photoaffinity labeling strategy identified fumarate hydratase as the principal pharmacological target.[1]
In vitro: The activity of this enzyme was measured using a well-established assay that monitored the conversion of fumarate into L-malate and subsequent oxidation of L-malate to oxaloacetate by malate dehydrogenase. Initial controls established that neither the carboxylic acid 3 nor ester 2 inhibited malate dehydrogenase Using this two-enzyme protocol we found that carboxylic acid 3 inhibited fumarate hydratase in a dose-dependent fashion in vitro. Besides, inhibition of fumarate hydratase can contribute to tumorigenicity in some cells.[1]
Menge: 10mM*1mL (in DMSO)
Lieferbar: In stock
Listenpreis: 302,86 €
Preis: 302,86 €
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