PGD2-IN-1

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mM*1mL (in DMSO)
ArtNr HY-101430-10mM
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
CAS No.
885066-67-1
Purity
>98%
MW
46035302
Formula
C23H23Cl2N3O3
Solubility
DMSO: >= 25 mg/mL
Biological Description
PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d); has an IC50 of 0.3 nM.
IC50 & Target: IC50: 0.3 nM[1]
In Vitro: Prostaglandin D2 (PGD2) is a major inflammatory mediator implicated in asthma and allergic rhinitis. It is largely produced as the major cyclooxygenase metabolite upon allergen-provoked degranulation from mast cells. Blockage of PGD2 using DP antagonists has been shown to be effective at alleviating the symptoms of allergic rhinitis in multiple species and more specifically has been shown to inhibit the antigen-induced nasal congestion[2].

Menge: 10mM*1mL (in DMSO)
Lieferbar: In stock
Listenpreis: 282,50 €
Preis: 282,50 €
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