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NPS-2143 (hydrochloride)

NPS-2143 (hydrochloride)

ArtNr	HY-10171-10mM
Hersteller	MedChem Express
CAS-Nr.	324523-20-8
Menge	10 mM/1 mL
Quantity options	10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Kategorie	Oncology Food Safety Hormones Neuroscience Metabolism Regulation of Appetite Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules By Organ Thyroid Cancer
Typ	Inhibitors
Specific against	other
Purity	99.98
Citations	[1]Huang Y, Breitwieser GE. Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis. J Biol Chem. 2007 Mar 30;282(13):9517-25\|[2]Marquis, Robert W.; Lago, Amparo M.; Callahan, James F.;Antagonists of the Calcium Receptor. 2. Amino Alcohol-Based Parathyroid Hormone Secretagogues. Journal of Medicinal Chemistry (2009), 52(21), 6599-6605.\|[3]Yamamura A, Guo Q, Yamamura H, Zimnicka AM, Pohl NM, Smith KA, Fernandez RA, Zeifman A, Makino A, Dong H, Yuan JX.Enhanced Ca2+-sensing receptor function in idiopathic pulmonary arterial hypertension.Circ Res. 2012 Aug 3;111(4):469-81. Epub 2012 Jun 22.\|[4]Nakajima S, Hira T, Hara H.Calcium-sensing receptor mediates dietary peptide-induced CCK secretion in enteroendocrine STC-1 cells.Mol Nutr Food Res. 2012 May;56(5):753-60.\|[5]Davey AE, Leach K, Valant C, Conigrave AD, Sexton PM, Christopoulos A.Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor.Endocrinology. 2012 Mar;153(3):1232-41. Epub 2011 Dec 30.\|[6]Nemeth EF, et al. Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone. J Pharmacol Exp Ther. 2001 Oct;299(1):323-31. FASEB Bioadv. 2025 Sep 3;7(8):e70045. University of Verona. 2025. Acta Physiol. 2023 Apr;237(4):e13926. Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1309-17. FEBS Open Bio. 2025 Oct 13. Food Chem. 2024 Oct 10;464(Pt 1):141569. Food Funct. 2022 Jun 6;13(11):6233-6243. Food Funct. 2025 Apr 14;16(8):3018-3027. Front Pharmacol. 2022 Feb 23:13:816133. Front Pharmacol. 2022 Feb 23;13:816133. Gen Comp Endocrinol. 2018 Oct 1:267:1-8. Int J Biol Sci. 2024 Jul 15;20(10):3892-3910. Int J Mol Med. 2021 Jan;47(1):302-314. Int J Mol Sci. 2023 Mar 3;24(5):4921. J Agric Food Chem. 2025 May 7;73(18):10998-11006. J Clin Endocrinol Metab. 2024 Oct 16:dgae735. J Food Sci. 2018 Sep;83(9):2394-2401. J Tradit Complement Med. 2024 Jul 2. J Vet Sci. 2018 Mar 31;19(2):179-187. Neurosci Lett. 2025 Aug 9:865:138351. Oxid Med Cell Longev. 2017:2017:3869561. Oxid Med Cell Longev. 2021 Jan 12;2021:3010548. Photochem Photobiol. 2022 Sep;98(5):1157-1166. Phytomedicine. 2021 Apr:84:153507. Sci Rep. 2025 May 9;15(1):16209. Sci Rep. 2019 Dec 12;9(1):18979. Toxicon. 2026 Jan:269:108660.
Smiles	N#CC1=C(OC[C@@H](CNC(C)(C)CC2=CC=C3C=CC=CC3=C2)O)C=CC=C1Cl.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SB-262470A (hydrochloride)
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Category	Reference compound / Active compounds
Manufacturer - Targets	CaSR
Manufacturer - HS Code	H302+H312+H332, H410
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	445.38
Product Description	NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor[1][2].
Manufacturer - Research Area	Metabolic Disease
Solubility	DMSO : ≥ 100 mg/mL\|H2O : 1.85 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	GPCR/G Protein
Clinical information	No Development Reported
UNSPSC Code	12352005
Precautionary	H302+H312+H332, H410

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