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Adezmapimod (hydrochloride)

Adezmapimod (hydrochloride)

ArtNr	HY-10256A-50mg
Hersteller	MedChem Express
CAS-Nr.	869185-85-3
Menge	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 200 mg 50 mg 5 mg
Kategorie	Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Neural Signaling Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.71
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Smiles	O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)C.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SB 203580 (hydrochloride),RWJ 64809 (hydrochloride)
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Autophagy; Mitophagy; Organoid; p38 MAPK
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	413.90
Product Description	Adezmapimod (SB 203580; RWJ 64809) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod hydrochloride does not disrupt JNK activity and is an autophagy and mitophagy activator[1].
Manufacturer - Research Area	Inflammation/Immunology; Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 5 mg/mL (ultrasonic)
Manufacturer - Pathway	Autophagy; MAPK/ERK Pathway; Stem Cell/Wnt
Clinical information	No Development Reported
Isoform	p38 MAPK; p38β

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