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PROTAC RAR Degrader-1

PROTAC RAR Degrader-1

ArtNr	HY-111844-1mg
Hersteller	MedChem Express
CAS-Nr.	1351169-27-1
Menge	1 mg
Quantity options	10 mg 1 mg 5 mg
Kategorie	Oncology By Cell Type Hematology Leukemia Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	97.91
Citations	[1]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.\|[2]Itoh Y, et al. Design, synthesis and biological evaluation of nuclear receptor-degradation inducers. Bioorg Med Chem. 2011 Nov 15;19(22):6768-78.
Smiles	O=C(O)C1=CC=C(/C=C/C(C2=CC(C(C)(C)C)=CC(C(C)(C)C)=C2)=O)C=C1OCCCNC(COCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@H](N)CC3=CC=CC=C3)=O)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1351169-27-1
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	PROTACs; RAR/RXR; SNIPERs
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, stored under nitrogen)
Molecular Weight	917.14
Product Description	PROTAC RAR degrader-1 (Compound 9) is a potent and selective RAR PROTAC Degrader consisting of apoptotic protein inhibitors (IAPs) ligands. IAPs-based degraders are also known as SNIPERs. PROTAC RAR Degrader-1 reduces RARα levels in HT1080 cells in a concentration-dependent manner but is blocked by the proteasome inhibitor MG132 (HY-13259). PROTAC RAR Degrader-1 can be used in the study of nuclear receptor-related diseases. (Pink: RAR ligand 1 (HY-111843); Black: Linker (HY-140189); Blue: IAPs Ligand (HY-B0134))[1][2].
Manufacturer - Research Area	Cancer; Metabolic Disease; Neurological Disease
Solubility	DMSO : ≥ 80 mg/mL
Manufacturer - Pathway	Metabolic Enzyme/Protease; PROTAC; Vitamin D Related/Nuclear Receptor
Clinical information	No Development Reported
Isoform	cIAP1; RXRα

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HY-111844-1mg-safety-datasheet.pdf