« Zurück
Startseite /
Chelerythrine (chloride)

Chelerythrine (chloride)

ArtNr	HY-12048-100mg
Hersteller	MedChem Express
CAS-Nr.	3895-92-9
Menge	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Kategorie	Oncology Neuroscience Metabolism Diabetes Glucose Homeostasis Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Bladder Cancer Breast Cancer
Typ	Inhibitors
Specific against	other
Purity	99.11
Citations	[1]Li W, et al. Effect of Chelerythrine Against Endotoxic Shock in Mice and Its Modulation of Inflammatory Mediators in Peritoneal Macrophages Through the Modulation of Mitogen-Activated Protein Kinase (MAPK) Pathway. Inflammation. 2012 Jul 24.\|[2]Pencikova K, et al. Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line. Phytomedicine. 2012 Jul 15;19(10):890-5. Epub 2012 May 14.\|[3]Chen XM, et al. Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines. Oncol Lett. 2016 Jun;11(6):3917-3924\|[4]Herbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172(3):993-9.\|[5]Chan SL, et al.Identification of chelerythrine as an inhibitor of BclXL function.J Biol Chem. 2003 Jun 6;278(23):20453-6.\|[6]Tang ZH, et al.Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells.Redox Biol. 2017 Aug;12:367-376. Cytokine. 2024 Jul 26:182:156717.\|Harvard Medical School LINCS LIBRARY\|Heliyon. 2024 Jul 28;10(15):e35368.\|J Headache Pain. 2022 Mar 8;23(1):35.\|J Inflamm Res. 2025 Mar 20:18:4213-4231.\|Phytother Res. 2023 Jul 4.\|Research Square Preprint. 2020 Oct.\|Sci Rep. 2017 Aug 23;7(1):9201.\|Biochem Biophys Res Commun. 2024 Oct 29:739:150914.\|Cancer Cell Int. 2023 Jun 17;23(1):117.\|Cell Commun Signal. 2021 Oct 11;19(1):103.\|FASEB J. 2019 Dec;33(12):13644-13659.\|Fishes. 2022, 7(5), 229.\|Front Pharmacol. 13 May 2021.\|Front Physiol. 2021 Oct 28;12:770430.\|Planta Med. 2024 Jun;90(7-08):523-533.
Smiles	C[N+]1=CC2=C(C(OC)=CC=C2C3=C1C4=CC5=C(OCO5)C=C4C=C3)OC.[Cl-]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	3895-92-9
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Apoptosis; Autophagy; Bcl-2 Family; PKC
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	383.82
Product Description	Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.
Manufacturer - Research Area	Cancer; Metabolic Disease; Inflammation/Immunology
Solubility	DMSO: 4.35 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Autophagy; Epigenetics; TGF-beta/Smad
Isoform	PKC
Clinical information	No Development Reported

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkt-Datenblatt anfordern

HY-12048-100mg-safety-datasheet.pdf