Z-Ile-Leu-aldehyde

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mg
ArtNr HY-12465-10mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
Z-IL-CHO, GSI-XII, gamma-Secretase inhibitor XII
CAS No.
161710-10-7
Purity
>98%
MW
3624632
Formula
C20H30N2O4
Solubility
DMSO: >= 41 mg/mL
Biological Description
Z-Ile-Leu-aldehyde(Z-IL-CHO; GSI-XII) is a potent gamma-Secretase inhibitor; Notch signaling inhibitor.
IC50 value:
Target: gamma-Secretase inhibitor
in vitro: GSI-XII induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity. GSI XII impairs murine osteoclast differentiation of receptor activator of NF-kappaB ligand (RANKL)-stimulated RAW264.7 cells in vitro [1]. Notch-signaling inhibition in HRS cells by the gamma-secretase inhibitor (GSI) XII results in decreased alternative p52/RelB NF-kappaB signaling, interfering with processing of the NF-kappaB2 gene product p100 into its active form p52 [2]. GSI treatment induced morphologic erythroid differentiation and promoted hemoglobin production. GSI treatment suppressed short-term growth and colony formation, while treatment with GSI-XXI promoted the growth of AA cells [3].
in vivo: In the murine MOPC315.BM myeloma model GSI XII has potent anti-MM activity and reduces osteolytic lesions as evidenced by diminished myeloma-specific monoclonal immunoglobulin (Ig)-A serum levels and quantitative assessment of bone structure changes via high-resolution microcomputed tomography scans [1].
Menge: 10mg
Lieferbar: In stock
Listenpreis: 636,07 €
Rabatt: -10,0%
Preis: 572,46 €
Sie sparen: 63,61 €
lieferbar

Angebot anfordern

Fragen zum Produkt?

Ihr Ansprechpartner:

Arne Pelz

sales@hoelzel.de

 
Schließen