Z-DEVD-FMK

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mg
ArtNr HY-12466-10mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
Caspase-3 Inhibitor
CAS No.
210344-95-9
Purity
>98%
MW
6686646
Formula
C30H41FN4O12
Solubility
DMSO: >= 33.33 mg/mL
Biological Description
Z-DEVD-FMK is a specific caspase-3 inhibitor with IC50 of 18 uM.



IC50 & Target: IC50: 18 uM (caspase-3)[1]
In Vitro: N27 cells are exposed to MPP+ in the absence or presence of 50 uM Z-DIPD-FMK or 100 uM Z-DEVD-FMK or 50 uM Z-LEHD-FMK and then caspase-9 and caspase-3 enzymatic activities are determined by enzymatic assay at 12 and 24 h following exposure, respectively. Exposure to 300 uM MPP+ for 24 h in N27 cells results in an approximately 2.5-fold increase in caspase-3 enzyme activity. MPP+-induced increases in caspase-3 enzyme activity are significantly blocked by 50 uM Z-DIPD-FMK, 100 uM Z-DEVD-FMK, and 50 uM Z-LEHD-FMK[1].
In Vivo: Early Z-DEVD-FMK (160 ng) treatment improves motor and cognitive function after traumatic CNS injury induced by severe controlled cortical impact (CCI) in the mouse[2]. Treatment with Z-DEVD-FMK (160 ng) significantly improves neurological outcome when compared with traumatized animals treated with DMSO vehicle (p<0.01)[3].
Publications
Apoptosis. 2016 Feb; 21(2):130-42.
Toxicol Appl Pharmacol. 2016 Feb 1; 292:56-64.
Menge: 10mg
Lieferbar: In stock
Listenpreis: 341,43 €
Preis: 341,43 €
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