VLX1570

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mM*1mL (in DMSO)
ArtNr HY-12471-10mM
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
VLX 1570, VLX-1570
CAS No.
1431280-51-1
Purity
>98%
MW
4693944
Formula
C23H17F2N3O6
Solubility
DMSO: >= 32 mg/mL
Biological Description
VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.
In vitor: VLX1570 was indeed found to inhibit USP14 in cells at a concentration of 1 uM.
target: DUBs
IC50: 4.2 uM to 8.6 uM
In vitro: 1) VLX1570 inhibits proteasome deubiqu-itinase activity and induces accumulation of high molecularweight. polyubiquitinated proteins in cells.
2) Knock-down of USP14 in multiple myeloma cells induces loss of cell viability.
3) VLX1570 induces accumulation of polyubiquitin chains and elicits apoptosis of multiple myeloma cells.
4) VLX1570 induces apoptosis and cell death of MM cells
In vivo: The reference for the injection is 5 mg/kg
Note: The compound was dissolved in 50% PEG400/40%Tween-80/10% Kolliphor EL and then diluted with saline.

Sicherheitsdatenblatt

HY-12471-10mM.pdf

Menge: 10mM*1mL (in DMSO)
Lieferbar: In stock
Listenpreis: 473,21 €
Rabatt: -10,0%
Preis: 425,89 €
Sie sparen: 47,32 €
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