Peptide 401

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 1mg
ArtNr HY-12537-1mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2, IKCNCKRHVIKPHICRKICGKN-NH2
CAS No.
32908-73-9
Purity
>98%
MW
2587, 215
Formula
C110H192N40O24S4
Solubility
DMSO
Clinical Phase
No Development Reported
Signalling Pathway
Immunology/Inflammation, GPCR/G Protein, Neuronal Signaling, GPCR/G Protein
Target
Histamine Receptor, Histamine Receptor, 5-HT Receptor, 5-HT Receptor
Biological Description
Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT). IC50 & Target: Histamine receptor[1]
5-HT receptor[1] In Vivo: Peptide 401 substantially inhibits the oedema provoked by subplantar injection of carrageenin or intra-articular injection of turpentine in the rat. The ED50 of 401 is c. 0.1 mg/kg. The anti-inflammatory effect is assessed by measurement of the increased 125I-albumin content of an injected site in comparison with an uninjected contralateral site. Peptide 401 also suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, bradykinin, 5-hydroxytryptamine (5-HT), and prostaglandins)[1]. Peptide 401 (MCD peptide) contains 22 residues and occurs in the venom of the common European honey bee to the extent of about 2% by weight . It has powerful anti-inflammatory activity (at doses as low as 0.1 mg/kg) in a variety of animal models, i.e., hind paw oedema in the rat induced by carrageenin or turpentine, adjuvant arthritis in the rat, and increased skin permeability in the rat resulting from subcutaneous injection of bradykinin, prostaglandin E1 kallikrein, histamine and 5- hydroxytryptamine (5-HT). It has a powerful degranulating effect on mast cells and involves the release of histamine and other pharmacologically active agents[2].
Menge: 1mg
Lieferbar: In stock
Listenpreis: 612,50 €
Preis: 612,50 €
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