PNU-282987

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 50mg
ArtNr HY-12560A-50mg
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
CAS No.
123464-89-1
Purity
>98%
MW
3012115
Formula
C14H18Cl2N2O
Solubility
DMSO: >= 61 mg/mL
Biological Description
PNU-282987 is a selective alpha7 nicotinic acetylcholine receptor(alpha7 nAChR) agonist with Ki of 26 nM; no affinity for alpha1beta1gammadelta and alpha3beta4 nAChRs (IC50 >= 60 uM).
IC50 value: 26 nM(Ki) [1]
Target: alpha7 nAChR agonist
in vitro: Treatment with PNU-282987 resulted in an attenuation of neuroinflammation in the MPTP-lesioned SN. Furthermore, PNU-282987 attenuated MPTP-induced dopaminergic cell loss in the SN and reduced striatal dopamine depletion [3].
in vivo: Mice were subjected to 70% partial hepatic I/R for 60 min and pretreated with either vehicle or with PNU-282987, and blood and hepatic tissue samples were collected at 3, 6, and 12 h following reperfusion. pretreatment with PNU-282987 decreased serum transaminase levels and ameliorated liver injury after hepatic I/R. Moreover, pretreatment with PNU-282987 suppressed NF-kappaB activation, cytokine production (tumor necrosis factor alpha, interleukin 1beta), and HMGB1 expression in liver after hepatic I/R [2]. Mice treated with 2.5 and 10 mg/kg of PNU devoted less time to rearing into open arms. In the HB task, MC mice displayed higher exploratory activity reflected in more head-dips (HD) during the first minute than EE and SE, whereas EE displayed low exploration levels reflected in total HD (5 min) [4].
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Journal
Dong Jun Yu, et al. Effect of ischemic preconditioning combined with alpha7 nAchR agonists on limb ischemia-reperfusion lung injury in rat.. Biomedical Research. 2017; Special Issue: ISSN 0970.
Menge: 50mg
Lieferbar: In stock
Listenpreis: 330,71 €
Rabatt: -10,0%
Preis: 297,64 €
Sie sparen: 33,07 €
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