ZM39923 (hydrochloride)

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 50mg
ArtNr HY-12589-50mg
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
Synonyms
ZM-39923 hydrochloride
CAS No.
1021868-92-7
Purity
>98%
MW
3679117
Formula
C23H26ClNO
Solubility
DMSO: >= 47 mg/mL
Biological Description
ZM39923 hydrochloride is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR, also found to be sensitive to transglutaminase.
IC50 value: 4.4/7.1 (pIC50)
Target: JAK1/3
in vitro: ZM39923 is a JAK3 inhibitor. ZM39923 is also a potent inhibitor of TGM2 with IC50 of 10 nM. ZM39923 is reversible inhibitors when TGM2 is incubated with inhibitors in the absence of Ca2+. ZM39923 shows significant inhibition of crosslinking activity with IC50 of 25 nM in the absence of DTT and IC50 of 10 uM in the presence of DTT. ZM39923 prevents early death in a Drosophila Melanogaster model of a polyQ repeat disorder called Machado-Joseph Disease. ZM39923 inhibits the generation of AICD-FLAG and both Abeta40 and Abeta42 by purified gamma-secretase in a concentration-dependent fashion with an approximate IC50 of 20 uM. ZM39923 decreases photoaffinity-labeled PS1-CTF in the presense of gamma-secretase.
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 50mg
Lieferbar: In stock
Listenpreis: 401,43 €
Rabatt: -10,0%
Preis: 361,29 €
Sie sparen: 40,14 €
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