« Zurück
Startseite /
3,5-Diiodothyropropionic acid

3,5-Diiodothyropropionic acid

ArtNr	HY-126236-5mg
Hersteller	MedChem Express
CAS-Nr.	1158-10-7
Menge	5 mg
Quantity options	10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Kategorie	Food Safety Inhibitors & Compound Libraries Small Molecules Food Additives Preservatives
Typ	Inhibitors
Specific against	other
Purity	99.20
Citations	[1]Pennock GD, et al. Cardiac effects of 3,5-diiodothyropropionic acid, a thyroid hormone analog with inotropic selectivity. J Pharmacol Exp Ther. 1992 Oct;263(1):163-9.\|[2]Liu Y, et al. Thyroid hormone analog 3,5-diiodothyropropionic acid promotes healthy vasculature in the adult myocardium independent of thyroid effects on cardiac function. Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1551-7. \|[3]Maitra N, et al. Regulation of gene expression in rats with heart failure treated with the thyroid hormone analog 3,5-diiodothyropropionic acid (DITPA) and the combination of DITPA and captopril. J Cardiovasc Pharmacol. 2007 Nov;50(5):526-34. \|[4]Mousa SA, et al. Proangiogenesis action of the thyroid hormone analog 3,5-diiodothyropropionic acid (DITPA) is initiated at the cell surface and is integrin mediated. Endocrinology. 2006 Apr;147(4):1602-7.
Smiles	O=C(O)CCC1=CC(I)=C(OC2=CC=C(O)C=C2)C(I)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1158-10-7
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Category	Reference compound / Active compounds
Manufacturer - Targets	Thyroid Hormone Receptor
Manufacturer - HS Code	H302, H315, H319, H335
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	510.06
Product Description	3, 5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (TR), with Ka of 2.40 and 4.06 M-1 for TRα1 and TRβ1, respectively. 3, 5-Diiodothyropropionic acid promotes angiogenesis in 3-D human dermal microvascular endothelial cell sprouting assay. 3, 5-Diiodothyropropionic acid prevents myocardial arteriolar loss in thyroidectomized rats and enhances cardiac energy-generating capacity in postinfarction heart failure rats. 3, 5-Diiodothyropropionic can be used in studies related to angiogenesis and heart failure[1][2][3][4].
Manufacturer - Research Area	Cardiovascular Disease; Endocrinology
Solubility	DMSO : 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Vitamin D Related/Nuclear Receptor
Clinical information	No Development Reported
UNSPSC Code	12352005
Precautionary	H302, H315, H319, H335

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.