Rhosin (hydrochloride)

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 5mg
ArtNr HY-12646-5mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
CAS No.
1281870-42-5
Purity
>98%
MW
3948575
Formula
C20H19ClN6O
Solubility
10 mM in DMSO
Biological Description
Rhosin Hcl is a specific Rho inhibitor; binds to WT RhoA with an affinity ca.0.4 uM Kd; does not interfere with the binding of Cdc42 or Rac1.
IC50 value: 0.4 uM(binding Kd) [1]
Target: RhoA inhibitor
Rhosin is specific to the interaction between RhoA and its GEFs including LARG, DBL, LBC, p115 RhoGEF or PDZ RhoGEF and does not interfere with the binding of Cdc42 or Rac1 to their respective GEFs. Rhosin showed a dose-dependent inhibition of endogenous RhoA activity and cell growth of MCF7 cells. Rhosin dose-dependently reduced RhoA and p-MLC1 activities of MCF7 cell-derived mammospheres with an EC50 ca.30-50uM, and caused decreased size and reduced number of mammospheres in MCF7 cells [1]. Y16 works synergistically with Rhosin/G04, a Rho GTPase activation site inhibitor, in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling functions [2].
Menge: 5mg
Lieferbar: In stock
Listenpreis: 460,36 €
Preis: 460,36 €
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