MPI-0479605

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mM*1mL (in DMSO)
ArtNr HY-12660-10mM
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
CAS No.
1246529-32-7
Purity
>98%
MW
407512
Formula
C22H29N7O
Solubility
DMSO: 11 mg/mL
Biological Description
MPI-0479605 is a potent, ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, > 40-fold selectivity over other kinases.
IC50 value: 1.8 nM
Target: Mps 1
in vitro: MPI-0479605 impairs the SAC and the bipolar attachment of chromosomes to the mitotic spindle, which results in chromosome segregation defects and aneuploidy. MPI-0479605 results in a significant decrease in cell viability with GI50 ranging from 30 to 100 nM in a panel of tumor cell lines. In addition, MPI-0479605 also causes cell growth arrest and ultimately promotes cell death by apoptosis or mitotic catastrophe.
in vivo: MPI-0479605 (30 mg/kg daily or 150 mg/kg every 4 days, i.p.) exhibits antitumor activity in colon cancer xenograft models.
Menge: 10mM*1mL (in DMSO)
Lieferbar: In stock
Listenpreis: 270,71 €
Preis: 270,71 €
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