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Bromocriptine (mesylate)

Bromocriptine (mesylate)

ArtNr	HY-12705A-10mM
Hersteller	MedChem Express
CAS-Nr.	22260-51-1
Menge	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 200 mg 50 mg 5 mg
Kategorie	Neuroscience Metabolism Cholesterol & Lipid Metabolism Targets for Rodent Neurosciences Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.98
Citations	[1]Gardner B, et al. Agonist action at D2(long) dopamine receptors: ligand binding and functional assays. Br J Pharmacol. 1998 Jul;124(5):978-84.\|[2]Renodon A, et al. Bromocriptine is a strong inhibitor of brain nitric oxide synthase: possible consequences for the origin of its therapeutic effects.FEBS Lett. 1997 Apr 7;406(1-2):33-6.\|[3]Wynalda MA, et al. Assessment of potential interactions between dopamine receptor agonists and various human cytochrome P450 enzymes using a simple in vitro inhibition screen. Drug Metab Dispos. 1997 Oct;25(10):1211-4.\|[4]Rana DG, et al. Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression. Ayu. 2014 Jan;35(1):90-7.\|[5]Dieb W, et al. Nigrostriatal dopaminergic depletion increases static orofacial allodynia. J Headache Pain. 2016;17:11. Aquaculture. 2025 Apr 15.\|BMC Endocr Disord. 2021 Nov 23;21(1):235.\|Br J Pharmacol. 2021 Apr 26.\|Eur J Integr Med. 2021, 101322.\|Eur J Pharmacol. 2022: 175443.\|Int J Mol Sci. 2024 Nov 21;25(23):12483.\|J Biomol Struct Dyn. 2021 Sep 22;1-12.\|J Endocrinol Invest. 2024 Jun 26.\|J Ethnopharmacol. 2021 Mar 9;113994.\|Nat Commun. 2020 Feb 18;11(1):941. \|Sci Adv. 2021 Nov 26;7(48):eabj4624.\|Mol Pharm. 2022 Oct 21.\|Pharmacogn Mag. 2023 Oct 12.\|Toxicol Appl Pharmacol. 2024 Mar 2:116876.
Smiles	[H][C@@]12CC3=C(Br)NC4=CC=CC(C1=C[C@@H](C(N[C@@]5(C(C)C)C(N6[C@@H](CC(C)C)C(N7CCC[C@]7([C@]6(O)O5)[H])=O)=O)=O)CN2C)=C43.OS(=O)(C)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CB-154
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Autophagy; Dopamine Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	750.70
Product Description	Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.
Manufacturer - Research Area	Neurological Disease; Cancer
Solubility	DMSO: 175 mg/mL (ultrasonic)\|H2O: 1.1 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Manufacturer - Pathway	Autophagy; GPCR/G Protein; Neuronal Signaling
Isoform	D2 Receptor
Clinical information	Launched

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HY-12705A-10mM-safety-datasheet.pdf