Rauwolscine hydrochloride

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 50mg
ArtNr HY-12710A-50mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
alpha-Yohimbine hydrochloride, Corynanthidine hydrochloride, Isoyohimbine hydrochloride
CAS No.
6211-32-1
Purity
>98%
MW
390, 90368
Formula
C21H27ClN2O3
Solubility
DMSO: 6 mg/mL (Need Altrasonic)
Clinical Phase
Launched
Signalling Pathway
GPCR/G Protein
Target
Adrenergic Receptor
Biological Description
Rauwolscine hydrochloride is a potent and specific alpha2 adrenergic receptor antagonist with a Ki of 12 nM. IC50 & Target: Ki: 12 nM (alpha2 adrenergic receptor)[1] In Vitro: [3H]Rauwolscine binding to alpha2 adrenergic receptor is reversible, stcreospccific, and saturable. [3H]Rauwolscine specifically labels both the high and low affinity states of the alpha2 adrenergic receptor in brain membranes[1]. [3H]Rauwolscine also behaves as a 5-HT1A receptor agonist and this conclusion is compatible with earlier functional studies, indicating that rauwolscine (as well as yohimbine) has agonistic properties at the level of 5-HT autoreceptors[2]. When using [3H]5-HT as a radioligand, rauwolscine is determined to have relatively high affinity for the human receptor (Ki human=14.3 nM, Ki rat=35.8 nM)[3]. Saturation studies shows that the affinity of [3H]Rauwolscine is similar in mouse, rat, rabbit, dog (2.33-3.03 nM) except man where it is significantly higher (0.98 nM) [4].
Menge: 50mg
Lieferbar: In stock
Listenpreis: 108,93 €
Preis: 108,93 €
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