Torin 1

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 50mg
ArtNr HY-13003-50mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
Torin1, Torin-1
CAS No.
1222998-36-8
Purity
>98%
MW
6076243
Formula
C35H28F3N5O2
Solubility
DMSO: 6.6 mg/mL (Need ultrasonic or warming)
Biological Description
Torin 1 is a potent inhibitor of mTORC, with IC50 values of 2 nM and 10 nM against mTORC1 and mTORC2, respectively.
IC50 & Target: IC50: 2 nM (mTORC1), 10 nM (mTORC2)
In Vitro: Torin1 (250 nM) completely inhibits proliferation and causes a G1/S cell cycle arrest, and decreases cell size to a greater degree than 50 nM rapamycin in wild-type MEFs[1]. Torin1 has more than 800-fold selectivity between mTOR and PI3Kis, and is very selective relative to other PIKK family kinases with the exception of DNA-PK[2].
In Vivo: Torin1 (20 mg/kg, i.p.) is efficacious in a U87MG xenograft model, and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues[2].
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 50mg
Lieferbar: In stock
Listenpreis: 501,07 €
Preis: 501,07 €
lieferbar

Angebot anfordern

Fragen zum Produkt?

Ihr Ansprechpartner:

Arne Pelz

sales@hoelzel.de

Schließen