RepSox

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 5mg
ArtNr HY-13012-5mg
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
Synonyms
E-616452, SJN 2511, E616452, SJN2511, E 616452, SJN-2511
CAS No.
446859-33-2
Purity
>98%
MW
2873186
Formula
C17H13N5
Solubility
DMSO: >= 52 mg/mL
Biological Description
RepSox(E-616452; SJN 2511) is a potent and selective inhibitor of the TGFbetaR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively.
IC50 Value: 23 nM
Target: ALK5
in vitro: Pretreated MEFs with RepSox, applying the chemical for three days, and then removed it at the time of transduction with Oct4, Klf4, and cMyc. In these experiments, no Oct4+GFP+ colonies were formed, suggesting that RepSox does not act on the initial somatic cells to replace Sox2. Consistent with this result, we did not detect a significant increase in the expression of endogenous Sox2or closely related Sox family members upon RepSox treatment [1]. RepSox did increase by 5-fold the expression of L-Myc, a close homolog of cMyc that can functionally replace it in reprogramming.
in vivo:
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Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Journal
Zha JS, et al. Phorbol esters dPPA/dPA promote furin expression involving transcription factor CEBPbeta in neuronal cells. Oncotarget. 2017 Jun 19; 8(36):60159-60172.
Menge: 5mg
Lieferbar: In stock
Listenpreis: 120,71 €
Rabatt: -10,0%
Preis: 108,64 €
Sie sparen: 12,07 €
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