SIS3

Hersteller MedChem Express
Kategorie Produkte / Inhibitors / Research Area / Oncology / Colorectal Cancer
Typ Inhibitors
Specific against other
Menge 10mg
ArtNr HY-13013-10mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
SIS 3, SIS-3
CAS No.
521984-48-5
Purity
>98%
MW
4899932
Formula
C28H28ClN3O3
Solubility
DMSO: >= 30 mg/mL
Biological Description
SIS3 is a potent and selective inhibitor of Smad3. a potent regulator of the human Nox4 promoter.
target: Smad3
SIS3 Reduces the TGF-beta1-Dependent Increase in Phosphorylation and DNA Binding of Smad3. SIS3 has no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. SIS3 can block excessive ECM production from the TGF-beta1-treated normal fibroblasts and scleroderma fibroblasts, the model of cells with autocrine TGF-beta signaling in vitro.
Publications
Int J Clin Exp Med. 2016; 9(8):15892-15899.
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 10mg
Lieferbar: In stock
Listenpreis: 296,43 €
Preis: 296,43 €
lieferbar

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