BI605906

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 5mg
ArtNr HY-13019-5mg
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
Synonyms
BI-605906
CAS No.
960293-88-3
Purity
>98%
MW
4325084
Formula
C17H22F2N4O3S2
Solubility
DMSO: >= 29 mg/mL
Biological Description
BI605906, a novel inhibitor of IKKbeta, inhibits IKKbeta with an IC50 value of 380 nM when assayed at 0.1 mM ATP.
IC50 value: 380 nM
Target: IKKbeta
in vitro: BI605906 is a novel pharmacological inhibitors of the IKK family, inhibits IKKbeta with an IC50 value of 380 nM when assayed at 0.1 mM ATP. The only other protein kinase that was inhibited of over 100 tested, which included IKKalpha and TBK1, was the IGF1 (insulin-like growth factor 1) receptor (IC50=7.6 uM). In IKKalpha / MEFs, BI605906 not only prevents the phosphorylation of physiological substrates, such as p105 and RelA, but also the phosphorylation of the serine residues in IKKbeta (Ser177 and Ser181) that trigger its activation.
Journal
Jaco I, et al. MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death. Mol Cell. 2017 Jun 1; 66(5):698-710.e5.
Menge: 5mg
Lieferbar: In stock
Listenpreis: 460,36 €
Rabatt: -10,0%
Preis: 414,32 €
Sie sparen: 46,04 €
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