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DAPT Europäischer Partner

ArtNr HY-13027-50mg
Hersteller MedChem Express
CAS-Nr. 208255-80-5
Menge 50 mg
Quantity options 100 mg 10mM/1mL 10 mg 50 mg 5 mg
Kategorie
Typ Inhibitors
Clon N/A
Specific against other
Purity 99.91
Formula C23H26F2N2O4
Citations [1]Dovey HF, et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem. 2001 Jan;76(1):173-81.<br/>[2]Zhou JX, et al. γ-secretase inhibition combined with NSC 119875 enhances apoptosis of nasopharyngeal carcinoma cells.Exp Ther Med. 2012 Feb;3(2):357-361.<br/>[3]Li S, et al. DAPT protects brain against cerebral ischemia by down-regulating the expression of Notch 1 and nuclear factor κB in rats. Neurol Sci. 2012 Dec;33(6):1257-64.<br/>[4]Tanimizu N, et al. Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement in mice. Hepatology. 2016 Jul;64(1):175-88.<br/>[5]Michael T. Chang, et al. Notch Drives Proliferation And Radiation Resistance Of Cancer Stem Cells In Adenoid Cystic Carcinoma. Yale University. January 2016.<br/>[6]Majumder S, et al. Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease. J Clin Invest. 2018 Jan 2;128(1):483-499.<br/>[7]Yixin Tao, et al. β-catenin activation in hair follicle dermal stem cells induces ectopic hair outgrowth and skin fibrosis. J Mol Cell Biol. 2018 May 16.
Smiles FC1=CC(F)=CC(CC(N[C@H](C(N[C@H](C(OC(C)(C)C)=O)C2=CC=CC=C2)=O)C)=O)=C1
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias GSI-IX
Lieferbar
Product Description
DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment[1][2].
StorageTemperature
-20°C, 3 years; 4°C, 2 years (Powder)
Shipping
Room Temperature
Manufacturers Applications
Cancer-programmed cell death
MolecularWeight
432.46
Clinical Information
No Development Reported
Manufacturers Research Area
Cancer; Inflammation/Immunology; Neurological Disease
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Target
Amyloid-β; Apoptosis; Autophagy; Notch; Organoid; γ-secretase
Manufacturers Target
Amyloid-β; Apoptosis; Autophagy; Notch; Organoid; γ-secretase
Manufacturers Pathway
Apoptosis; Autophagy; Neuronal Signaling; Stem Cell/Wnt
Manufacturers Product type
Reference compound

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50 mg
Lieferbar: In stock
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