LX-1031

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 25mg
ArtNr HY-13041-25mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
CAS
945976-76-1
MWt
538.5177
Formula
C28H25F3N4O4
Solubility
DMSO: >= 34 mg/mL
Clinical_Information
Phase 2
Pathway
Metabolic Enzyme/Protease
Target
Tryptophan Hydroxylase
Biological Activity
LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally.
In Vivo: With oral administration of LX-1031 in mice, the average 5-HT reductions in the jejunum relative to control are appr 33, 51, and 66% with the 15, 45 and 135 mg/kg/day doses respectively. In a preliminary report, the effects of LX-1031, 100 mg/kg daily, on 5-HT levels in jejunal mucosa are reversible within 2 days of discontinuation in mice[1]. LX-1031 dose-dependently reduces expression of 5-HT in the duodenum, jejunum and ileum, but has no effect on brain 5-HT levels in preclinical assay[2].
Menge: 25mg
Lieferbar: In stock
Listenpreis: 823,57 €
Preis: 823,57 €
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