LX1606 (Hippurate)

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 100mg
ArtNr HY-13055-100mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
Telotristat etiprate, LX 1606 Hippurate, LX-1606 Hippurate
CAS No.
1137608-69-5
Purity
>98%
MW
7541546
Formula
C36H35ClF3N7O6
Solubility
DMSO: >= 28 mg/mL
Biological Description
LX1606 Hippurate is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
In Vivo: LX1606 (15, 50, 150, 300 mg/kg, po, qd) reduces serotonin content in the periphery, but not in the brain of the mice. LX1606 (200 mg/kg po, qd) prevents the increase in blood neutrophil counts that is observed after TNBS challenge, provides significant protection in a mouse model of inflammatory bowel disease. LX1606 (200 mg/kg po, qd) protects the mouse IBD model confirmed by histopathology evaluation[1]. LX1606 (15, 50, 150, 300 mg/kg) depletes 5-HT from the jejunum but not the brain. But LX1606 (200 mg/kg, p.o.) does not deplete enteric neuronal serotonin (5-HT), or alter constitutive gastrointestinal motility in mice. LX1606 (200 mg/kg) alleviates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis[2].
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 100mg
Lieferbar: In stock
Listenpreis: 1.689,29 €
Rabatt: -10,0%
Preis: 1.520,36 €
Sie sparen: 168,93 €
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