Nocodazole

ArtNr	HY-13520-50mg
Hersteller	MedChem Express
CAS-Nr.	31430-18-9
Menge	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Kategorie	Oncology Neuroscience Neural Mitochondrial Function Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Heart & Blood Cancer
Typ	Inhibitors
Specific against	other
Purity	99.59
Citations	[1]Park H, et al. Nocodazole is a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK. ChemMedChem. 2012 Jan 2;7(1):53-6.\|[2]Keliang Xu, et al. Interaction of nocodazole with tubulin isotypes. Drug Development Research 2002\|[3]Wang YJ, et al. R-41400 potentiates the antitumor effects of nocodazole: In vivo therapy for human tumor xenografts in nude mice. Mol Carcinog. 2002 Aug;34(4):199-210.\|[4]Signoretto E, et al. Nocodazole Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem. 2016;38(1):379-92.\|[5]Zhang JP, et al. Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage. Genome Biol. 2017 Feb 20;18(1):35.\|[6]Anutosh Ganguly, et al. The role of microtubules and their dynamics in cell migration. J Biol Chem. 2012 Dec 21;287(52):43359-69.
Smiles	O=C(OC)NC1=NC2=CC=C(C(C3=CC=CS3)=O)C=C2N1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Oncodazole,R17934
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Apoptosis; Autophagy; Bcr-Abl; CRISPR/Cas9; Microtubule/Tubulin; Mitosis
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	301.32
Product Description	Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Protein Tyrosine Kinase/RTK
Isoform	Abl
Clinical information	No Development Reported

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HY-13520-50mg-safety-datasheet.pdf