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Sitagliptin (phosphate monohydrate)

Sitagliptin (phosphate monohydrate)

ArtNr	HY-13749B-10mM
Hersteller	MedChem Express
CAS-Nr.	654671-77-9
Menge	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 1 g 200 mg 500 mg
Kategorie	Neuroscience Aging & Neurological Disorders Neural Signaling Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.83
Citations	[1]Thomas, L., et al. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylm ethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of acti\|[2]Kim, S.J., et al., Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation. Diabetes, 2009. 58(3): p. 641-51.\|[3]Sangle, G.V., et al., Novel biological action of the dipeptidylpeptidase-IV inhibitor, sitagliptin, as a GLP-1 secretagogue. Endocrinology, 2012. 153(2): p. 564-73.\|[4]Kim, S.J., et al., Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice. Diabetes, 2008. 57(5): p. 1331-9.\|[5]Beconi, M.G., et al. Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs. Drug Metab Dispos, 2007. 35(4): p. 525-32. Biomed Pharmacother. 2023 Mar 24;162:114555.\|bioRxiv. 2023 Nov 4.\|Biochem Pharmacol. 2023 Oct 5:115846.\|Biochim Biophys Acta Mol Basis Dis. 2024 Jul 25:167433.\|Cell Death Dis. 2021 Oct 11;12(10):928.\|Exp Cell Res. 2024 Sep 12;442(2):114254.\|Front Oncol. 24 September 2021.\|iScience. 2023 Feb.\|J Adv Res. 2024 Oct 5:S2090-1232(24)00433-8.\|J Biol Chem. 2018 Dec 7;293(49):18864-18878. \|J Nanobiotechnology. 2024 Oct 16;22(1):631.\|J Sep Sci. 2021 Oct 28.\|Korean J Physiol Pharmacol. 2021 Sep 1;25(5):425-437.\|Life Metab. 2025 Feb 08.\|Neurol Res. 2018 Sep;40(9):736-743.\|Nutr Neurosci. 2018 Apr 26:1-17.\|Nutrition. 2024 Aug 29.\|Orebro University. 2024.\|Oxid Med Cell Longev. 2019 Nov 15;2019:6181754.\|Oxid Med Cell Longev. 2022 May 17;2022:2586305.\|Research Square Preprint. 2024 Apr 25.\|Sci Rep. 2019 Mar 11;9(1):4074.
Smiles	[H]O[H].O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=C(F)C=C3F.O=P(O)(O)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MK-0431 (phosphate monohydrate)
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	Autophagy; Dipeptidyl Peptidase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	523.32
Product Description	Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts[1].
Manufacturer - Research Area	Metabolic Disease; Cancer
Solubility	H2O : ≥ 33 mg/mL
Manufacturer - Pathway	Autophagy; Metabolic Enzyme/Protease
Clinical information	Launched
Isoform	DPP-4

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