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Vinblastine (sulfate)

Vinblastine (sulfate)

ArtNr	HY-13780-10mM
Hersteller	MedChem Express
CAS-Nr.	143-67-9
Menge	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Kategorie	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Colorectal Cancer Testicular & Prostate Cancer
Typ	Inhibitors
Specific against	other
Purity	99.86
Citations	[1]McKay DB, et al. Nicotinic and nonnicotinic receptor-mediated actions of vinblastine. Proc Soc Exp Biol Med. 1993 Jul;203(3):372-6.\|[2]Pandya P, et al. Molecular recognition pattern of cytotoxic alkaloid vinblastine with multiple targets. J Mol Graph Model. 2014 Nov;54:1-9.\|[3]Calvi?o E, et al. JNK and NFκB dependence of apoptosis induced by vinblastine in human acute promyelocytic leukaemia cells. Cell Biochem Funct. 2015 Jun;33(4):211-9.\|[4]Selimovic D, et al. Vinblastine-induced apoptosis of melanoma cells is mediated by Ras homologous A protein (Rho A) via mitochondrial and non-mitochondrial-dependent mechanisms. Apoptosis. 2013 Aug;18(8):980-97.\|[5]Bánóczi Z, et al. Synthesis and in vitro antitumor effect of vinblastine derivative-oligoarginine conjugates. Bioconjug Chem. 2010 Nov 17;21(11):1948-55. Biochem Pharmacol. 2020 May;175:113865.\|bioRxiv. 2025 Jan 24:2025.01.22.632572.\|Cancer Immunol Res. 2023 May 3;11(5):583-599.\|Cell Rep Methods. 2023 Oct 23;3(10):100599.\|Cells. 2022, 11(19), 2942.\|Int J Biol Macromol. 2022 Jun 16;S0141-8130(22)01308-3.\|J Biol Chem. 2021, 100525.\|Mol Cell Biochem. 2021 Feb;476(2):1233-1243.\|Mol Pharm. 2022 Oct 21.\|Mutat Res Genet Toxicol Environ Mutagen. 2016 Sep 15;808:27-37. \|PLoS Pathog. 2021 Aug 9;17(8):e1009838.\|Food Chem. 2023 Jun 22, 136707.\|Int J Clin Exp Pathol. 2017;10(3):3033-3042.
Smiles	[H][C@@]12C[C@@](C3=C(OC)C=C(N([C@]4([H])[C@@]56[C@]7([H])[C@](C=CCN7CC6)(CC)[C@@H](OC(C)=O)[C@@]4(C(OC)=O)O)C)C5=C3)(C(OC)=O)C(NC8=C9C=CC=C8)=C9CC[N@](C2)C[C@](O)(CC)C1.OS(=O)(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Vincaleukoblastine sulfate salt
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Autophagy; Microtubule/Tubulin; nAChR
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	909.05
Product Description	Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.
Manufacturer - Research Area	Cancer
Solubility	DMSO: ≥ 44 mg/mL\|H2O: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Membrane Transporter/Ion Channel; Neuronal Signaling
Clinical information	Launched

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HY-13780-10mM-safety-datasheet.pdf