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Pemetrexed (disodium hemipenta hydrate)

Pemetrexed (disodium hemipenta hydrate)

ArtNr	HY-13781-10mM
Hersteller	MedChem Express
CAS-Nr.	357166-30-4
Menge	10mM/1mL
Quantity options	100 mg 10mM/1mL 500 mg
Kategorie	Oncology Neuroscience Neural Lineage Markers Targets for Rodent Neurosciences Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Oligodendrocyte Markers
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.78
Formula	C20H24N5Na2O8.5
Citations	J Mol Med (Berl). 2019 Aug;97(8):1183-1193. Acta Pharmacol Sin. 2021 Jan;42(1):108-114. Adv Ther. 2024 Jul 18. Biol Methods Protoc. 2025 Feb 13. bioRxiv. 2024 June 12. bioRxiv. 2025 January 21. bioRxiv. 2025 January 22. Br J Cancer. 2023 Jun 27. Cell Death Discov. 2022 Jul 5;8(1):307. Cell Rep Med. 2023 Jan 10;100911. Cell Rep Methods. 2023 Oct 23;3(10):100599. Commun Biol. 2022 Jun 23;5(1):619. Heliyon. 2024 Nov 8;10(22):e40299. Int Immunopharmacol. 2023 Nov 3;125(Pt A):111158. Integr Cancer Ther. 2024 Jan-Dec:23:15347354241273962. J Clin Invest. 2021 Aug 2;131(15):e138022. J Control Release. 2022 Dec 9;353:490-506. J Pharm Anal. 2024 Apr 25:100984. Mol Cancer. 2024 Jan 10;23(1):12. Pharmacol Res Perspect. 2020 Apr;8(2):e00575. Pharmacol Res. 2024 May 9:204:107208. Research Square Print. September 27th, 2022. Theranostics. 2020 May 15;10(13):6048-6060. Beilstein J Org Chem. 2017 Oct 25;13:2252-2263. Clin Transl Oncol. 2022 Jul 19. Faculty of the Graduate School of Biomedical Sciences. The University of Texas Southwestern Medical Center. Oct 1. 2015. J Mol Med (Berl). 2019 Aug;97(8):1183-1193. Mol Cell. 2019 Dec 5;76(5):838-851.e5. Odontology. 2020 Apr;108(2):300-311. [1]Shih C, et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57(6):1116-23. [2]Anraku M, et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma. J Immunol. 2010 Jul 15;185(2):956-66.
Smiles	O=C(O[Na])CC[C@@H](C(O[Na])=O)NC(C1=CC=C(CCC2=CNC(N=C(N)N3)=C2C3=O)C=C1)=O.[2.5H2O]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	LY231514 (disodium hemipenta hydrate)
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Antifolate; Apoptosis; Autophagy
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	516.41
Product Description	Pemetrexed disodium hemipenta hydrate is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.
Manufacturer - Research Area	Cancer
Solubility	DMSO : 2 mg/mL (ultrasonic)\|H2O : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Autophagy; Cell Cycle/DNA Damage
Clinical information	Launched

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HY-13781-10mM-safety-datasheet.pdf