Cimetidine

ArtNr	HY-14289-5g
Hersteller	MedChem Express
CAS-Nr.	51481-61-9
Menge	5 g
Quantity options	100 mg 10 g 10mM/1mL 1 g 5 g
Kategorie	Oncology Food Safety Histamines Neuroscience Neural Lineage Markers Aging & Neurological Disorders Neural Adhesion Molecules Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Lymphatic System Cancer Uterine, Ovarian & Cervical Cancer
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	98.0
Formula	C10H16N6S
Citations	[1]Takahashi, H.K., et al., Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol, 2006. 70(2): p. 450-3. [2]Sprowl, J.A., et al., Conjunctive therapy of cisplatin with the OCT2 inhibitor cimetidine: influence on antitumor efficacy and systemic clearance. Clin Pharmacol Ther, 2013. 94(5): p. 585-92. [3]Zheng, Y., et al., Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells. Mol Immunol, 2013. 54(1): p. 74-83. [4]Fukuda, M., K. Kusama, and H. Sakashita, Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression. BMC Cancer, 2008. 8: p. 376. [5]Longhini, R., et al., Cimetidine Reduces the Alveolar Bone Loss in Induced Periodontitis in Rat Molars. J Periodontol, 2013. [6]M J Smit, et al. Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6802-7.
Smiles	CC1=C(CSCC/N=C(NC)/NC#N)NC=N1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SKF-92334
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Bacterial; Histamine Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	252.34
Product Description	Cimetidine (SKF-92334) is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine has anti-cancer and anti-inflammatory activity[1][2][5].
Manufacturer - Research Area	Cancer; Endocrinology; Cardiovascular Disease
Solubility	DMSO : 60 mg/mL (ultrasonic)\|H2O : 2 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Isoform	H2 Receptor; Histamine Receptor
Clinical information	Launched

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