Fabomotizole

ArtNr	HY-14895-100mg
Hersteller	MedChem Express
CAS-Nr.	173352-21-1
Menge	100 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Kategorie	Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Inhibitors & Compound Libraries Small Molecules Neuronal Cell Markers
Typ	Inhibitors
Specific against	other
Purity	99.96
Citations	[1]Tsorin IB, et al. Anti-Ischemic Activity of Fabomotizole Hydrochloride under Conditions of Endothelial Dysfunction. Bull Exp Biol Med. 2019 Sep;167(5):634-636. \|[2]Pérez-Villanueva J, et al. The giardicidal activity of lobendazole, fabomotizole, tenatoprazole and ipriflavone: A ligand-based virtual screening and in vitro study. Eur J Med Chem. 2021 Feb 5;211:113110. \|[3]Chernykh I V, et al. Study of fabomotizole belonging to p-glycoprotein substrates[J]. IP Pavlov Russian Medical Biological Herald, 2017, 25(4): 538-550.\|[4]Voronin MV, Vakhitova YV, Tsypysheva IP, Tsypyshev DO, Rybina IV, Kurbanov RD, Abramova EV, Seredenin SB. Involvement of Chaperone Sigma1R in the Anxiolytic Effect of Fabomotizole. Int J Mol Sci. 2021 May 21;22(11):5455.
Smiles	CCOC1=CC=C2C(N=C(SCCN3CCOCC3)N2)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CM346
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Monoamine Oxidase; Parasite; P-glycoprotein; Sigma Receptor
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	307.41
Product Description	Fabomotizole (CM346) is an insecticide with anxiolytic, antianxiety, and neuroprotective activities and a substrate of p-glycoprotein. Fabomotizole inhibits the ST-segment depression induced by isoproterenol in a rat model of acute subendocardial ischemia. Fabomotizole also inhibits Giardia lamblia and has the potential to inhibit giardiasis. Fabomotizole also targets Sigma1R, NRH:quinone reductase 2 (NQO2), and MAO-A to exert anxiolytic effects[1][2][3].
Manufacturer - Research Area	Infection; Neurological Disease; Cardiovascular Disease
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling
Isoform	MAO-A; Sigma 1 Receptor
Clinical information	Launched

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HY-14895-100mg-safety-datasheet.pdf