Ceritinib

ArtNr	HY-15656-2g
Hersteller	MedChem Express
CAS-Nr.	1032900-25-6
Menge	2 g
Quantity options	100 mg 10 g 10mM/1mL 10 mg 1 g 1 mg 200 mg 2 g 500 mg 50 mg 5 g 5 mg
Kategorie	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Signaling Neural Adhesion Molecules Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Bladder Cancer Lymphatic System Cancer Calcium Binding Protein Markers
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.98
Formula	C28H36ClN5O3S
Citations	AMB Express. 2022 Nov 28;12(1):150. Biochim Biophys Acta Mol Cell Res. 2020 Jul;1867(7):118712. Biol Methods Protoc. 2025 Feb 13. Cancer Chemother Pharmacol. 2018 Aug;82(2):251-263. Cell Chem Biol. 2018 Aug 16;25(8):996-1005.e4. Cell Discov. 2021 May 11;7(1):33. Cell Physiol Biochem. 2018;45(4):1707-1716. Cell Rep Med. 2023 Jan 10;100911. Cell Signal. 2022 Jan 24;92:110264. Eur J Drug Metab Pharmacokinet. 2021 Jul 18;1-11. Eur J Med Chem. 2022: 114946. Fundam Clin Pharmacol. 2021 Feb 1. Harvard Medical School LINCS LIBRARY J Med Chem. 2024 Oct 3. J Pharm Pharmacol. 2020 Oct;72(10):1370-1382. J Transl Med. 2021 Feb 27;19(1):91. Mol Oncol. 2017 Aug;11(8):996-1006. Mol Syst Biol. 2023 Dec 18. Nat Cancer. 2022 Oct;3(10):1211-1227. Nat Commun. 2024 Apr 23;15(1):3422. Patent. US20200276189A1. Patent. US20230158019A1. PLoS One. 2024 Nov 1;19(11):e0308647. PLoS One. 2025 Jan 21;20(1):e0308747. RSC Adv. 2023 Mar 10;13(12):7929-7938. Sci Signal. 2015 Dec 8;8(406):ra125. Sci Transl Med. 2018 Jul 18;10(450):eaaq1093. Science. 2017 Dec 1;358(6367):eaan4368. Toxicol Appl Pharmacol. 2019 Nov 15;383:114781. Universitat Autònoma de Barcelona. Biologia Molecular i Biomedicina. 2022 Aug. Uppsala University. Department of Pharmaceutical Biosciences. 2022 Feb. Xenobiotica. 2018 Oct;48(10):1059-1071. bioRxiv. 2023 Jul 19. [1]Marsilje TH, et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. J Med Chem. 2013 Jul 25;56(14):5675-90. [2]Chen J, et al. LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor. J Med Chem. 2013 Jul 25;56(14):5673-4. [3]Tucker ER, et al. Immunoassays for the quantification of ALK and phosphorylated ALK support the evaluation of on-target ALK inhibitors in neuroblastoma. Mol Oncol. 2017 Aug;11(8):996-1006. [4]Rothschild SI. Ceritinib-a second-generation ALK inhibitor overcoming resistance in ALK-rearranged non-small celllung cancer. Transl Lung Cancer Res. 2014 Dec;3(6):379-81.
Smiles	CC(C)OC1=CC(C2CCNCC2)=C(C)C=C1NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	LDK378
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Anaplastic lymphoma kinase (ALK); IGF-1R; Insulin Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	558.14
Product Description	Ceritinib (LDK378) is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib (LDK378) also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib (LDK378) shows great antitumor potency[1][2].
Manufacturer - Research Area	Cancer; Endocrinology
Solubility	DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Protein Tyrosine Kinase/RTK
Clinical information	Launched

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