Sivelestat

ArtNr	HY-17443-50mg
Hersteller	MedChem Express
CAS-Nr.	127373-66-4
Menge	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Kategorie	Oncology Cardiovascular Research Atherosclerosis Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Typ	Inhibitors
Specific against	other
Purity	99.34
Citations	[1]Kawabata K, et al. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20.\|[2]Yuichiro Toda, et al. A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats. Int J Mol Med. 2007 Feb;19(2):237-43.\|[3]Tomoharu Kono, et al. Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. Mol Cell Biochem. 2008 Apr;311(1-2):87-92.\|[4]Adeleh Sahebnasagh, et al. Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. J Clin Pharm Ther. 2020 Aug 28. Biofabrication. 2021 Apr 8;13(3):10.1088/1758-5090/abe1cf. Brain Behav Immun. 2024 Jun 12:120:403-412. Burns Trauma. 2021 Sep 17:9:tkab030. Cancers (Basel). 2022 Jan 20;14(3):515. Cell Biosci. 2022 Jul 22;12(1):114. Ecotoxicol Environ Saf. 2023 Dec:268:115694. Elife. 2022 Mar 23:11:e77444. Exp Mol Med. 2024 Dec;56(12):2602-2616. Exp Mol Med. 2025 Sep;57(9):2067-2082. FASEB J. 2024 Dec 15;38(23):e70238. Heliyon. 2024 Oct 5;10(19):e38895. Int Immunopharmacol. 2025 Jul 31:163:115276. J Cell Mol Med. 2022 Apr;26(7):2089-2103. J Exp Med. 2023 Sep 4;220(9):e20221751. J Infect Dis. 2024 May 15;229(5):1352-1365. J Tissue Eng. 2025 Aug 19:16:20417314251348038. Nat Commun. 2025 Feb 5;16(1):1378. Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121. PLoS One. 2025 Nov 6;20(11):e0336333. Res Sq. 2024 Jul 30. Res Sq. 2025 May 08. Research Square Preprint. 2021 Aug. Research Square Preprint. 2021 Jun. Research Square Preprint. 2023 Dec 11. J Hepatocell Carcinoma. 2021 May 20:8:451-465. J Neuroinflammation. 2025 Aug 26;22(1):206. Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121. Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121. Oxid Med Cell Longev. 2019 Nov 23;2019:7323986.
Smiles	CC(C)(C)C(OC1=CC=C(S(=O)(NC2=CC=CC=C2C(NCC(O)=O)=O)=O)C=C1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	EI546,LY544349,ONO5046
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Category	Reference compound / Active compounds; API
Manufacturer - Targets	Elastase; SARS-CoV
Manufacturer - HS Code	H302, H315, H319, H335
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	434.46
Product Description	Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4].
Manufacturer - Research Area	Cancer
Solubility	DMSO : ≥ 100 mg/mL\|Ethanol : 3.03 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Metabolic Enzyme/Protease
Clinical information	Launched
UNSPSC Code	12352005
Precautionary	H302, H315, H319, H335

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