Losartan

ArtNr	HY-17512-10mM
Hersteller	MedChem Express
CAS-Nr.	114798-26-4
Menge	10 mM/1 mL
Quantity options	10 mM/1 mL 1 g 500 mg 5 g
Kategorie	Oncology Neuroscience Neural Signaling Cardiovascular Research Heart Failure Hypertension Inhibitors & Compound Libraries Small Molecules By Organ Uterine, Ovarian & Cervical Cancer
Typ	Inhibitors
Specific against	other
Purity	99.55
Citations	[1]Burnier, M. Angiotensin II type 1 receptor blockers. Circulation, 2001. 103(6): p. 904-12.\|[2]Ashry, O., et al. Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respir Physiol Neurobiol, 2014.\|[3]Choi, C.H., et al. Angiotensin II type I receptor and miR-155 in endometrial cancers: synergistic antiproliferative effects of anti-miR-155 and losartan on endometrial cancer cells. Gynecol Oncol, 2012. 126(1): p. 124-31.\|[4]Habashi, J.P., et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science, 2006. 312(5770): p. 117-21.\|[5]Campbell, D.J., et al. Effects of losartan on angiotensin and bradykinin peptides and angiotensin-converting enzyme. J Cardiovasc Pharmacol, 1995. 26(2): p. 233-40. Adv Healthc Mater. 2025 Mar 13:e2500176.\|Adv Sci (Weinh). 2024 Dec 5:e2410360.\|Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H580-H592.\|Am J Physiol Renal Physiol. 2020 Nov 1;319(5):F941-F953.\|Antioxidants (Basel). 2024 Aug 7;13(8):958.\|Apoptosis. 2024 Jun 9.\|Arch Biol Sci. 2021 Jun.\|Biochem Biophys Res Commun. 2025 Jan:745:151256.\|Biomolecules. 2022, 12(12), 1754.\|Biomolecules. 2023 Apr 25, 13(5), 740.\|Clin Sci. 2021 Mar 26;135(6):793-810.\|Clin Transl Med. 2023 Mar;13(3):e1213.\|FASEB J. 2018 Sep;32(9):5051-5062.\|Friedrich-Alexander University Erlangen-Nuremberg. 2023 May 2.\|Front Physiol. 2020 Sep 8;11:560170.\|Gene. 2022 Jan 31;146239.\|Int Immunopharmacol. 2023 Aug 4;123:110761.\|Int Immunopharmacol. 2024 Jul 19:139:112707.\|Int J Mol Sci. 2023 Feb 3;24(3):2960.\|Int J Nanomedicine. 2018 Nov 13;13:7409-7426. \|J Immunother Cancer. 2024 Sep 6;12(9):e009327.\|J Mol Cell Cardiol. 2025 Mar 21:S0022-2828(25)00055-0.\|J Orthop Surg Res. 2024 Feb 19;19(1):147.\|J Pharmacol Sci. 2020 Sep;144(1):30-42.\|J Physiol. 2023 Dec 28.\|J Transl Med. 2024 Jan 5;22(1):26.\|Mol Biomed. 2025 Feb 11;6(1):10.\|Nefrologia. 2023 Sep 6.\|Oncogene. 2023 Feb 23.\|Oxid Med Cell Longev. 2022 Feb 18;2022:5044046.\|Phytomedicine. 2022 Mar 21;100:154067.\|Phytomedicine. 2023 Feb 4;112:154700.\|Rep Biochem Mol Biol. 2021 Aug.\|Rep Biochem Mol Biol. 2021 Jul;10(2):314-326.\|Res Sq. 2024 Jul 16.\|Research Square Print. September 13th, 2022.\|Sci Rep. 2019 Dec 19;9(1):19450.\|Toxicol Appl Pharmacol. 2024 Apr 28:486:116945.\|Toxicol Lett. 2025 Feb 21:S0378-4274(25)00032-3.\|Cell Death Dis. 2020 May 22;11(5):390.\|Chem Biol Interact. 2023 Jul 14;110636.\|FASEB J. 2019 May;33(5):6254-6268. \|Phytomedicine. 2024 Dec 3:136:156314.
Smiles	OCC1=C(Cl)N=C(CCCC)N1CC2=CC=C(C3=CC=CC=C3C4=NNN=N4)C=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	DuP-753
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Angiotensin Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	422.91
Product Description	Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
Manufacturer - Research Area	Cardiovascular Disease; Endocrinology; Cancer
Solubility	DMSO: ≥ 100 mg/mL
Manufacturer - Pathway	GPCR/G Protein
Isoform	AT1 Receptor
Clinical information	Launched

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HY-17512-10mM-safety-datasheet.pdf