RS102895

ArtNr	HY-18611A-10mg
Hersteller	MedChem Express
CAS-Nr.	300815-41-2
Menge	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 25 mg 50 mg 5 mg
Kategorie	Oncology Neuroscience Neuroinflammation Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer
Typ	Inhibitors
Specific against	other
Purity	99.97
Citations	[1]Mirzadegan T, et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem. 2000 Aug 18;275(33):25562-71.\|[2]Park J, et al. MCP-1/CCR2 system is involved in high glucose-induced fibronectin and type IV collagen expression in cultured mesangial cells. Am J Physiol Renal Physiol. 2008 Sep;295(3):F749-57.\|[3]Ren F, et al. Analgesic Effect of Intrathecal Administration of Chemokine Receptor CCR2 Antagonist is Related to Change in Spinal NR2B, nNOS, and SIGIRR Expression in Rat with Bone Cancer Pain. Cell Biochem Biophys. 2015 Jun;72(2):611-6. Eur J Pharmacol. 2021, 174165.\|Exp Cell Res. 2020 Nov 1;396(1):112289.\|Hum Reprod. 2019 Apr 1;34(4):646-658.\|J Eur Acad Dermatol Venereol. 2020 Apr;34(4):862-872.\|J Interferon Cytokine Res. 2019 Apr;39(4):224-232. \|J Interferon Cytokine Res. 2020 May;40(5):245-253.\|Life Sci. 2020 Nov 15;261:118360.\|Stem Cell Res Ther. 2021 Jul 2;12(1):378.\|Stem Cell Res Ther. 2025 Mar 1;16(1):108.\|Brain Sci. 2025 Feb 27.\|Cell Death Dis. 2022 Feb 17;13(2):158.\|Int Immunopharmacol. 2023 Feb.\|J Adv Res. 2020 Jul 22;28:231-243.\|J Adv Res. 2024 Apr 14:S2090-1232(24)00155-3.\|J Neuroinflammation. 2023 Nov 17;20(1):270.\|Liver Int. 2022 Sep 27.\|Mol Med Rep. 2017 Sep;16(3):3387-3394. \|Nat Immunol. 2024 Sep 02.\|Sci Adv. 2023 Aug 2;9(31):eadg6856.\|Theranostics. 2020 Apr 27;10(13):5687-5703
Smiles	O=C1NC2=CC=CC=C2C3(CCN(CCC4=CC=C(C(F)(F)F)C=C4)CC3)O1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	300815-41-2
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	CCR
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	390.40
Product Description	RS102895 is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1.
Manufacturer - Research Area	Neurological Disease; Endocrinology
Solubility	DMSO: 175 mg/mL (ultrasonic)\|Ethanol: 50 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	GPCR/G Protein; Immunology/Inflammation
Isoform	CCR1; CCR2
Clinical information	No Development Reported

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HY-18611A-10mg-safety-datasheet.pdf