DDP-38003 (dihydrochloride)

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 50mg
ArtNr HY-19612A-50mg
Eclass 6.1 30220300
Eclass 9.0 32160605
Lieferbar
Synonyms
DDP 38003 dihydrochloride, DDP38003 dihydrochloride
CAS No.
1831167-98-6
Purity
>98%
MW
42337922
Formula
C21H28Cl2N4O
Solubility
DMSO: >= 29 mg/mL
Biological Description
DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM.
IC50 & Target: IC50: 84 nM (KDM1A/LSD1)[1]
In Vitro: DDP-38003 inhibits KDM1A with an IC50 of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue[1].
In Vivo: DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 is a potential oral anticancer agent[1].
Menge: 50mg
Lieferbar: In stock
Listenpreis: 1.807,14 €
Rabatt: -10,0%
Preis: 1.626,43 €
Sie sparen: 180,71 €
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