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Pasireotide (ditrifluoroacetate)

Pasireotide (ditrifluoroacetate)

ArtNr	HY-79135-10mM
Hersteller	MedChem Express
Menge	10mM/1mL
Quantity options	10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Kategorie	Oncology Neuroscience Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Pancreatic Cancer Nervous System Cancer
Typ	Inhibitors
Specific against	other
Purity	99.56
Formula	C62H68F6N10O13
Citations	Am J Pathol. 2018 Apr;188(4):981-994. Communications Medicine. 2, 80 (2022). Hepatology. 2017 Oct;66(4):1197-1218. Universidad De Salamanca. Biología y Clínica del Cáncer y Medicina Traslacional. 2022 Oct. Basic Clin Pharmacol Toxicol. 2022 Jun 10. J Clin Invest. 2024 October 1. [1]Lewis I, et, al. A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential. J Med Chem. 2003 Jun 5;46(12):2334-44. [2]Quinn TJ, et, al. Pasireotide (SOM230) is effective for the treatment of pancreatic neuroendocrine tumors (PNETs) in a multiple endocrine neoplasia type 1 (MEN1) conditional knockout mouse model. Surgery. 2012 Dec;152(6):1068-77. [3]Imhof AK, et, al. Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune-mediated arthritis. Arthritis Rheum. 2011 Aug;63(8):2352-62.
Smiles	O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.NCCCC[C@@H](C(N[C@H]1CC2=CC=C(C=C2)OCC3=CC=CC=C3)=O)NC([C@H](NC([C@H](C4=CC=CC=C4)NC([C@H]5N(C([C@H](CC6=CC=CC=C6)NC1=O)=O)C[C@H](OC(NCCN)=O)C5)=O)=O)CC7=CNC8=C7C=CC=C8)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SOM230 ditrifluoroacetate; Pasireotide TFA salt
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Peptides
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Somatostatin Receptor
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture)
Molecular Weight	1275.25
Product Description	Pasireotide (SOM230) ditrifluoroacetate, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/[1][2].
Manufacturer - Research Area	Endocrinology; Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 33.33 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Clinical information	Launched

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HY-79135-10mM-safety-datasheet.pdf