Flutamide

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 5g
ArtNr HY-B0022-5g
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
Synonyms
SCH 13521
CAS No.
13311-84-7
Purity
>98%
MW
2762119
Formula
C11H11F3N2O3
Solubility
10 mM in DMSO
Biological Description
Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer.
Target: androgen receptor
in vitro: Flutamide (Eulexin) is an antiandrogen drug. Flutamide-OH, the active metabolite of flutamide, directly binds at rat anterior pituitary androgen receptor with Ki values of 55 nM [1]. lutamide does not affect the proliferation of an androgen-sensitive clone of the mouse mammary carcinoma Shionogi SC-l 15 cells in culture, shows only antiandrogenic effect, but not androgenic effect [2]. Flutamide provides treatment for prostate cancer when used along with leuprolide [3].
in vivo: Flutamide causes a markedly reduction in rat ventral prostate weight from 319 mg to 245 mg. A combination of flutamide and LHRH agonist induces an additive effect with a decrease in prostate weight to 101 mg, and an marked drop in prostatic ODC activity [4].
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 5g
Lieferbar: In stock
Listenpreis: 149,64 €
Rabatt: -10,0%
Preis: 134,68 €
Sie sparen: 14,96 €
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