Vigabatrin (Hydrochloride)

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 5mg
ArtNr HY-B0033-5mg
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
Synonyms
gamma-Vinyl-GABA hydrochloride
CAS No.
1391054-02-6
Purity
>98%
MW
165618
Formula
C6H12ClNO2
Solubility
10 mM in DMSO
Biological Description
Vigabatrin Hcl(gamma-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.
IC50 value:
Target: GABA transaminase
Clinical studies have shown that vigabatrin is superior to placebo in decreasing the frequency of infantile spasms. In tuberous sclerosis, vigabatrin may be considered the first-line treatment for IS. The mode of action is increasing concentrations of the inhibitory neurotransmitter GABA in the brain.A significant increase in seizure threshold was observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of vigabatrin. Bilateral microinjection of vigabatrin (10 ug) into either the anterior or posterior SNr also increased seizure threshold, but less markedly than systemic treatment.
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 5mg
Lieferbar: In stock
Listenpreis: 108,93 €
Rabatt: -10,0%
Preis: 98,04 €
Sie sparen: 10,89 €
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