Pyrazinamide

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 50g
ArtNr HY-B0271-50g
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
Synonyms
Pyrazinecarboxamide, Pyrazinoic acid amide
CAS No.
98-96-4
Purity
>98%
MW
1231127
Formula
C5H5N3O
Solubility
10 mM in DMSO
Biological Description
Pyrazinamide is a pyrazine that is used therapeutically as an antitubercular agent.
Target: Antibacterial
Pyrazinamide is a prodrug that stops the growth of Mycobacterium tuberculosis. Pyrazinoic acid was thought to inhibit the enzyme fatty acid synthase (FAS) I, which is required by the bacterium to synthesise fatty acids although this has been discounted. It was also suggested that the accumulation of pyrazinoic acid disrupts membrane potential and interferes with energy production, necessary for survival of M. tuberculosis at an acidic site of infection. Pyrazinoic acid binds to the ribosomal protein S1 (RpsA) and inhibits trans-translation. This may explain the ability of the drug to kill dormant mycobacteria [1-4].
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 50g
Lieferbar: In stock
Listenpreis: 190,36 €
Rabatt: -10,0%
Preis: 171,32 €
Sie sparen: 19,04 €
lieferbar

Vergleichen

Angebot anfordern

Fragen zum Produkt?
 
Schließen