Cromolyn (disodium)

ArtNr	HY-B0320A-1g
Hersteller	MedChem Express
CAS-Nr.	15826-37-6
Menge	1 g
Quantity options	10 mM/1 mL 1 g 500 mg 5 g
Kategorie	Oncology Food Safety Histamines Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Typ	Inhibitors
Specific against	other
Purity	99.93
Citations	[1]Oka T, et al. Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice. Lab Invest. 2012 Oct;92(10):1472-82.\|[2]Arumugam T, et al. Effect of cromolyn on S100P interactions with RAGE and pancreatic cancer growth and invasion in mouse models. J Natl Cancer Inst. 2006 Dec 20;98(24):1806-18.\|[3]Granucci EJ, et al. Cromolyn sodium delays disease onset and is neuroprotective in the SOD1G93A Mouse Model of amyotrophic lateral sclerosis. Sci Rep. 2019 Nov 27;9(1):17728.\|[4]Zhang C, et al. Cromolyn Reduces Levels of the Alzheimer's Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis. Sci Rep. 2018 Jan 18;8(1):1144.\|[5]Motawi TM, et al. Naproxen and cromolyn as new glycogen synthase kinase 3β inhibitors for amelioration of diabetes and obesity: an investigation by docking simulation and subsequent in vitro/in vivo biochemical evaluation. J Biochem Mol Toxicol. 2013 Sep;27(9):425-36. J Ethnopharmacol. 2023: 116093.\|J Med Chem. 2021 Sep 21.\|Nat Commun. 2025 Jan 8;16(1):509.\|Pharmacol Res. 2017 Nov;125(Pt B):150-160.\|Int J Mol Sci. 2025 Feb 14.
Smiles	OC(COC1=C2C(C=C(C(O[Na])=O)OC2=CC=C1)=O)COC3=C4C(C=C(C(O[Na])=O)OC4=CC=C3)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Cromoglycate (disodium),Cromoglicic acid (disodium),FPL-670
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Amyloid-β; GSK-3; NF-κB
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light, stored under nitrogen)
Molecular Weight	512.33
Product Description	Cromolyn (Cromoglycate) disodium is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn disodium is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn disodium can be used in the research of bronchial asthma. In addition, Cromolyn disodium has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects[1][2][3][4][5].
Manufacturer - Research Area	Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease
Solubility	DMSO: 25 mg/mL (ultrasonic)\|H2O: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Neuronal Signaling; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Isoform	GSK-3β
Clinical information	Launched

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