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Ciprofloxacin (monohydrochloride) Europäischer Partner

ArtNr HY-B0356A-10mM
Hersteller MedChem Express
CAS-Nr. 93107-08-5
Menge 10 mMx1 mL
Quantity options 10 mMx1 mL 1 g 500 mg 5 g
Kategorie
Typ Inhibitors
Specific against other
Purity 99.90
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bioRxiv. 2024 Jan 18.
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EBioMedicine. 2022 Apr;78:103943.
Front Microbiol. 2022 Feb 16;12:773664.
Genome Biol. 2023 Apr 30;24(1):98.
Int J Antimicrob Agents. 2018 Aug;52(2):269-271.
iScience. 2023 Oct 5.
J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858.
Microb Pathog. 2024 Apr 27:106666.
Microbiol Spectr. 2022 Apr 25:e0251821.
Microbiol Spectr. 2022 Jan 12;e0099121.
Molecules. 2023 Jun 8, 28(12), 4628.
Nat Cell Biol. 2024 Jul 12.
Nature. 2024 Aug;632(8027):1137-1144.
NPJ Biofilms Microbiomes. 2024 Oct 28;10(1):111.
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PLoS Pathog. 2024 Dec 31;20(12):e1012783.
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[1]Tsai WC, et, al. Ciprofloxacin-mediated cell proliferation inhibition and G2/M cell cycle arrest in rat tendon cells. Arthritis Rheum. 2008 Jun;58(6):1657-63.
[2]Steenbergen J, et, al. In Vitro and In Vivo Activity of Omadacycline against Two Biothreat Pathogens, Bacillus anthracis and Yersinia pestis. Antimicrob Agents Chemother. 2017 Apr 24;61(5):e02434-16.
[3]Hamblin KA, et, al. Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague. Front Microbiol. 2017 Feb 6;8:91.
[4]LeMaire SA, et, al. Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice. JAMA Surg. 2018 Sep 1;153(9):e181804.
Smiles [H]Cl.O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CCNCC4)=C3)C1=O)O
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias Bay-09867 (monohydrochloride)
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Type
Reference compound
Manufacturer - Applications
COVID-19-immunoregulation
Manufacturer - Targets
Antibiotic; Apoptosis; Bacterial; Mitochondrial Metabolism; Reactive Oxygen Species; Topoisomerase
Shipping Temperature
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight
367.808
Product Description
Ciprofloxacin (Bay-09867) monohydrochloride is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin monohydrochloride induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin monohydrochloride has anti-proliferative activity and induces apoptosis. Ciprofloxacin monohydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[1][2][3][4].
Manufacturer - Research Area
Infection; Cancer
Solubility
DMSO : 5 mg/mL (ultrasonic)|H2O : 12.5 mg/mL (ultrasonic)
Manufacturer - Pathway
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Isoform
Quinolone
Clinical information
Launched

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 10 mMx1 mL
Lieferbar: In stock
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