Nitrendipine

ArtNr	HY-B0424-200mg
Hersteller	MedChem Express
CAS-Nr.	39562-70-4
Menge	200 mg
Quantity options	100 mg 10 mM/1 mL 1 g 200 mg 500 mg 50 mg
Kategorie	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer
Typ	Inhibitors
Specific against	other
Purity	99.36
Citations	[1]Bellemann, P., et al., [3H]-Nitrendipine, a potent calcium antagonist, binds with high affinity to cardiac membranes. Arzneimittelforschung, 1981. 31(12): p. 2064-7.\|[2]S Kazda, et al. Diuretic effect of nitrendipine contributes to its antihypertensive efficacy: a review. J Cardiovasc Pharmacol. 1988;12 Suppl 4:S1-5.\|[3]He-Hui Xie, et al. Synergism of atenolol and nitrendipine on hemodynamic amelioration and organ protection in hypertensive rats. J Hypertens. 2005 Jan;23(1):193-201.\|[4]Rivera I, et al. Nitrendipine, an antihypertensive alpha calcium channel blocker, is cytotoxic to neuroblastoma cells. Molecular & Cellular Toxicology, 2019, 15: 469-475.\|[5]Watson WP, et al. The differential effects of felodipine and nitrendipine on cerebral dihydropyridine binding ex vivo and the ethanol withdrawal syndrome in mice. Br J Pharmacol. 1994 Aug;112(4):1017-24.\|[6]RABANI, et al. Acute and chronic effects of nitrendipine on naloxone precipitated morphine withdrawal in mice. 2004, 109-114.\|[7]Gatch MB. Nitrendipine blocks the nociceptive effects of chronically administered ethanol. Alcohol Clin Exp Res. 2002 Aug;26(8):1181-7.\|[8]Aktay G, et al. Protective Effect of Nitrendipine on Naphthalene-Induced Oxidative Stress. Eczacilik Fakultesi Dergisi-Gazi Universitesi, 2000, 17(1): 19-24. \|[9]Michael JR, et al. Nitrendipine attenuates the pulmonary vascular remodeling and right ventricular hypertrophy caused by intermittent hypoxia in rats. Am Rev Respir Dis. 1986 Mar;133(3):375-9. \|[10]Han P, et al. Synergism of hydrochlorothiazide and nitrendipine on reduction of blood pressure and blood pressure variability in spontaneously hypertensive rats. Acta Pharmacol Sin. 2006 Dec;27(12):1575-9. \|[11]M Bursztyn, et al. Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats. Hypertension. 1994 Jun;23(6 Pt 2):1051-3.
Smiles	O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BAY-E-5009
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Apoptosis; Calcium Channel
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	360.36
Product Description	Nitrendipine (BAY-E-5009) is an orally active analog of Nifedipine (HY-B0284) and dihydropyridine calcium channel blocker. Nitrendipine induces Apoptosis. Nitrendipine has antihypertensive effects. Nitrendipine blocks alcohol and Morphine withdrawal symptoms. Nitrendipine reduces right ventricular hypertrophy and pulmonary vascular changes induced by intermittent hypoxia. Nitrendipine has anticancer effects on neuroblastoma[1][2][3][4][5][6][7][8][9][10][11].
Manufacturer - Research Area	Cancer; Neurological Disease; Cardiovascular Disease
Solubility	DMSO: 50 mg/mL (ultrasonic)\|H2O: < 0.1 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Clinical information	Launched

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