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Dequalinium (Chloride)

Dequalinium (Chloride)

ArtNr	HY-B0567-50mg
Hersteller	MedChem Express
CAS-Nr.	522-51-0
Menge	50 mg
Quantity options	100 mg 10 mMx1 mL 10 mg 25 mg 50 mg
Kategorie	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Head & Neck Cancer
Typ	Inhibitors
Specific against	other
Purity	99.91
Citations	[1]Kramer, W., [Treatment of tonsillitis with dequalinium chloride]. Fortschr Med, 1977. 95(16): p. 1108-10.\|[2]Gamboa-Vujicic, G., et al., Toxicity of the mitochondrial poison dequalinium chloride in a murine model system. J Pharm Sci, 1993. 82(3): p. 231-5.\|[3]Belanger-Coast MG, et al. Dequalinium chloride is an antagonists of α7 nicotinic acetylcholine receptors. Eur J Pharmacol. 2022 Jun 15;925:175000.\|[4]Mendling W, et al. Use of locally delivered dequalinium chloride in the treatment of vaginal infections: a review. Arch Gynecol Obstet. 2016 Mar;293(3):469-84.\|[5]Castle NA, et al. Dequalinium: a potent inhibitor of apamin-sensitive K+ channels in hepatocytes and of nicotinic responses in skeletal muscle. Eur J Pharmacol. 1993 May 19;236(2):201-7.\|[6]Bugay V, et al. Effects of Sublethal Organophosphate Toxicity and Anti-cholinergics on Electroencephalogram and Respiratory Mechanics in Mice. Front Neurosci. 2022 May 2;16:866899.\|[7]Abdul M, et al. Expression and activity of potassium ion channels in human prostate cancer. Cancer Lett. 2002 Dec 1;186(1):99-105.
Smiles	CC1=[N+](C2=CC=CC=C2C(N)=C1)CCCCCCCCCC[N+](C3=CC=CC=C3C(N)=C4)=C4C.[Cl-].[Cl-]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	522-51-0
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Apoptosis; Bacterial; nAChR; Parasite; Potassium Channel
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	527.57
Product Description	Dequalinium chloride is an Apamin (HY-P0256)-sensitive potassium channel selective blocker. Dequalinium chloride is a cationic, lipophilic mitochondrial poison. Dequalinium chloride is also an antagonist pf α7 nAChR, and an anti-microbial antiseptic agent with a broad bactericidal and fungicidal activity[1][2][3][4].
Manufacturer - Research Area	Cancer; Infection
Solubility	DMSO: < 1 mg/mL\|H2O: 0.99 mg/mL (ultrasonic; warming; adjust pH to 3 with 1 M HCl; heat to 60°C)
Manufacturer - Pathway	Anti-infection; Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Clinical information	Launched

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HY-B0567-50mg-safety-datasheet.pdf