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Amodiaquine (dihydrochloride dihydrate)

Amodiaquine (dihydrochloride dihydrate)

ArtNr	HY-B1322-10mM
Hersteller	MedChem Express
CAS-Nr.	6398-98-7
Menge	10mM/1mL
Quantity options	100 mg 10mM/1mL
Kategorie	Food Safety Histamines Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.89
Formula	C20H22ClN3O.2H2O.2HCl
Citations	Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868. Bioorg Chem. 2024 Apr 29:147:107412. Cell Signal. 2025 Mar 2:131:111706. Biol Pharm Bull. 2022 Feb 3. Metab Brain Dis. 2021 Jan 28. Research Square Print. September 20th, 2022. J Virol. 2024 Jan 18:e0121623. Oxid Med Cell Longev. 2021 Feb 10. Pharmacol Res. 2023 Mar 20;106717. [1]Chun-Hyung Kim, et al. Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8756-61. [2]Keita Kinoshita, et al. A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage. J Neuroimmunol. 2019 May 15;330:48-54. [3]Akira Yokoyama, et al. Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. Eur J Pharmacol. 2007 Mar 8;558(1-3):179-84. [4]M T HOEKENGA. The treatment of acute malaria with single oral doses of amodiaquin, chloroquine, hydroxychloroquine and pyrimethamine. Am J Trop Med Hyg. 1954 Sep;3(5):833-8.
Smiles	OC1=CC=C(NC2=CC=NC3=CC(Cl)=CC=C23)C=C1CN(CC)CC.Cl.Cl.O.O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Amodiaquin (dihydrochloride dihydrate)
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Histone Methyltransferase; Nuclear Hormone Receptor 4A/NR4A; Parasite
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	464.81
Product Description	Amodiaquine dihydrochloride dihydrate (Amodiaquin dihydrochloride dihydrate), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine dihydrochloride dihydrate is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect[1][2][3][4].
Manufacturer - Research Area	Infection; Inflammation/Immunology; Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 20 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Epigenetics; Vitamin D Related/Nuclear Receptor
Isoform	Nurr1/NR4A2; Plasmodium
Clinical information	Launched

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HY-B1322-10mM-safety-datasheet.pdf