Serotonin (hydrochloride)

Neuroscience-Neuromodulation

Room Temperature

212.68

Neurological Disease

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 uM.
IC50 & Target: 5-HT receptor^[1]

Ki: 44 uM (COMT)^[1]
In Vitro: Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (K_i=?44 uM). Results show that addition of 100 uM of Serotonin hydrochloride decreases the reaction velocity of COMT^[1].
In Vivo: Serotonin hydrochloride produces robust hypersensitivity compare to saline-treated controls (p<0.001)^[1]. A significant increase in colonic 5-HT content is observed in IL-13^-/- mice receiving Serotonin hydrochloride compare to IL-13^-/- receiving vehicle following induction of DSS colitis^[2].