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Tranylcypromine (hemisulfate)

Tranylcypromine (hemisulfate)

ArtNr	HY-B1496-10mM
Hersteller	MedChem Express
CAS-Nr.	13492-01-8
Menge	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL
Kategorie	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Brain Cancer
Typ	Inhibitors
Specific against	other
Purity	99.94
Citations	[1]Caraci F, et al. Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1-42)-induced toxicity. Eur J Pharmacol. 2015 Oct 5;764:256-263.\|[2]Sun Q, et al. Tranylcypromine, a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Reprod Biol Endocrinol. 2016 Apr 9;14:17.\|[3]Tsutsumi T, et al. Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6461-6473.\|[4]Romanczyk TB, et al. The antidepressant tranylcypromine alters cellular proliferation and migration in the adult goldfish brain. Anat Rec (Hoboken). 2014 Oct;297(10):1919-26. Biochem Biophys Res Commun. 2019 May 14;512(4):852-858.\|Biol Reprod. 2020 Dec 1;103(6):1229-1237.\|Biomaterials. 2018 Dec 6;193:30-46.\|Patent. US20180263995A1.\|Stem Cell Res Ther. 2020 Apr 16;11(1):157.
Smiles	N[C@H]1[C@H](C2=CC=CC=C2)C1.[0.5H2SO4]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SKF 385 (hemisulfate)
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	Histone Demethylase; Monoamine Oxidase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	182.23
Product Description	Tranylcypromine (SKF 385) hemisulfate is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hemisulfate is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Tranylcypromine has antidepressant effects[1][2].
Manufacturer - Research Area	Neurological Disease; Cancer
Solubility	DMSO: 5 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O: 12.5 mg/mL (ultrasonic)
Manufacturer - Pathway	Epigenetics; Neuronal Signaling
Isoform	KDM1/LSD1
Clinical information	Launched

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HY-B1496-10mM-safety-datasheet.pdf